In this paper our aim is to examine whether research conducted on human participants with LSD-25 raises unique research ethical questions or demands particular concerns with regard to the design, conduct and follow-up of these studies, and should this be the case, explore and describe those issues. Our analysis is based on reviewing publications up to date which examine the clinical, research and other uses of LSD and those addressing ethical and methodological concerns of these applications, just as some historical (...) examinations of this subject. The first chapters of the paper give an overview regarding the history of LSD-research with human participants, healthy volunteers and patients alike. The remaining chapters have a focus on questions regarding the potential ethical issues of such human trials in the contemporary research ethics framework. We also consider briefly political and regulatory issues regarding this substance that possibly affect its clinical and research applications. (shrink)

BackgroundThe areas of Research Ethics (RE) and Research Integrity (RI) are rapidly evolving. Cases of research misconduct, other transgressions related to RE and RI, and forms of ethically questionable behaviors have been frequently published. The objective of this scoping review was to collect RE and RI cases, analyze their main characteristics, and discuss how these cases are represented in the scientific literature.MethodsThe search included cases involving a violation of, or misbehavior, poor judgment, or detrimental research practice in relation to a (...) normative framework. A search was conducted in PubMed, Web of Science, SCOPUS, JSTOR, Ovid, and Science Direct in March 2018, without language or date restriction. Data relating to the articles and the cases were extracted from case descriptions.ResultsA total of 14,719 records were identified, and 388 items were included in the qualitative synthesis. The papers contained 500 case descriptions. After applying the eligibility criteria, 238 cases were included in the analysis. In the case analysis, fabrication and falsification were the most frequently tagged violations (44.9%). The non-adherence to pertinent laws and regulations, such as lack of informed consent and REC approval, was the second most frequently tagged violation (15.7%), followed by patient safety issues (11.1%) and plagiarism (6.9%). 80.8% of cases were from the Medical and Health Sciences, 11.5% from the Natural Sciences, 4.3% from Social Sciences, 2.1% from Engineering and Technology, and 1.3% from Humanities. Paper retraction was the most prevalent sanction (45.4%), followed by exclusion from funding applications (35.5%).ConclusionsCase descriptions found in academic journals are dominated by discussions regarding prominent cases and are mainly published in the news section of journals. Our results show that there is an overrepresentation of biomedical research cases over other scientific fields compared to its proportion in scientific publications. The cases mostly involve fabrication, falsification, and patient safety issues. This finding could have a significant impact on the academic representation of misbehaviors. The predominance of fabrication and falsification cases might diverge the attention of the academic community from relevant but less visible violations, and from recently emerging forms of misbehaviors. (shrink)

Studien zum Entstehen der Philosophie Wittgensteins János Kristóf Nyíri. BEIM STERNENLICHT DER NICHTEXISTIERENDEN: ZUR IDEOLOGIEKRITISCHEN INTERPRETATION DES PLA- TONISIERENDEN ANTIPSYCHOLOGISMUS* ...

The paper examines the difference between János Bolyai’s and Lobachevskii’s notion of non-Euclidean parallelism. The examination starts with the summary of a widespread view of historians of mathematics on János Bolyai’s notion of non-Euclidean parallelism used in the first paragraph of his Appendix. After this a novel position of the location and meaning of Bolyai’s term “parallela” in his Appendix is put forward. After that János Bolyai’s Hungarian manuscript, the Commentary on Lobachevskii’s Geometrische Untersuchungen is elaborated in (...) order to see how Bolyai and Lobachevskii’s notions of parallelism differ. The careful examination of the Commentary reveals a seeming incoherence of Bolyai’s translation, and finally the explanation of this incoherence offered by the Received View and that of the novel position will be compared and assessed. L’article examine la différence entre la notion du parallélisme non-Euclidean de János Bolyai et celle de Lobachevskii. Tout d’abord le travail s’occupe de l’opinion répendue parmi les historiens de géometrie (le « Received View » ), selon laquelle János Bolyai précise la notion du parallélisme non-Euclidean dans le premier paragraph de l’Appendix. Ensuite une pointe de vue toute neuve sera présentée concernant la place et le sens du terminus technicus,,paralella” de Bolyai dans l’Appendix. Enfin on va analyser les Commentaires (un manuscrit hongrois) de János Bolyai sur le livre Geometrische Untersuchungen de Lobachevskii àfin de voir jusqu’à quel point la notion de parallelisme de Bolyai se diffère de celle de Lobachevskii. L’analyse bien fondue des Commentaires va nous relever un apparent incohérence de la traduction de Bolyai. On examine et on compare l’opinion répendue dans le vaste public avec la nouvelle interpretation de l’Appendix, et on discute les explications probables de cet incohérence. (shrink)

Fairness in machine learning (ML) is an ever-growing field of research due to the manifold potential for harm from algorithmic discrimination. To prevent such harm, a large body of literature develops new approaches to quantify fairness. Here, we investigate how one can divert the quantification of fairness by describing a practice we call “fairness hacking” for the purpose of shrouding unfairness in algorithms. This impacts end-users who rely on learning algorithms, as well as the broader community interested in fair AI (...) practices. We introduce two different categories of fairness hacking in reference to the established concept of p-hacking. The first category, intra-metric fairness hacking, describes the misuse of a particular metric by adding or removing sensitive attributes from the analysis. In this context, countermeasures that have been developed to prevent or reduce p-hacking can be applied to similarly prevent or reduce fairness hacking. The second category of fairness hacking is inter-metric fairness hacking. Inter-metric fairness hacking is the search for a specific fair metric with given attributes. We argue that countermeasures to prevent or reduce inter-metric fairness hacking are still in their infancy. Finally, we demonstrate both types of fairness hacking using real datasets. Our paper intends to serve as a guidance for discussions within the fair ML community to prevent or reduce the misuse of fairness metrics, and thus reduce overall harm from ML applications. (shrink)

The dialectical-theological origins of the politically- and ethically-charged concept of alterity are well-known within the philosophy of religion. Intellectual histories of this concept tie it too exclusively to the notion of distance or διάστασις in Karl Barth’s early Römerbrief, however, and so miss Barth’s Trinitarian reinterpretation of God’s otherness in his later work. Taking as my hermeneutical key a cipher, the ‘sign of Jonah,’ that emerges in Church Dogmatics IV/1, I show that Barth’s mature doctrines of temporality and filiation understand (...) alterity as a moment of divine life. Jesus’ agony in the garden of Gethsemane marks the climax of Barth’s self-reinterpretation: world history inheres within the Christological situation of paternal abandonment. The political-theological conclusions Barth draws from the ‘sign of Jonah’ dovetail with alterity discourses’ antitotalitarian aspirations but suggest that these aspirations’ structural coherence rest on the magisterial Reformers’ Christological and ecclesiological commitments. (shrink)

What if language was an autonomous historical being? What if language’s use was not solely dependent on the intentions of the one who speaks? In this text I will test these provocative statements. Specifically, I will investigate whether language’s proclaimed historical independence can be traced in the usage of the concept of ‘secularisation’, and I will try to unveil the consequences of this operation.Contribution: Has Christianity abandoned the public stage in the ‘secularised’ and industrialised world? In this article I intend (...) to demonstrate that this is not the case. The continuous operative presence of Christianity in our socio-political language is used as the model to prove this argument. (shrink)

Intertemporal choice involves deciding between smaller, sooner and larger, later rewards. People tend to prefer smaller rewards that are available earlier to larger rewards available later, a phenomenon referred to as temporal or delay discounting. Despite its ubiquity in human and non-human animals, temporal discounting is subject to considerable individual differences. Here, we provide a critical narrative review of this literature and make suggestions for future work. We conclude that temporal discounting is associated with key socio-economic and health-related variables. Regarding (...) personality, large-scale studies have found steeper temporal discounting to be associated with higher levels of self-reported impulsivity and extraversion; however, effect sizes are small. Temporal discounting correlates negatively with future-oriented cognitive styles and inhibitory control, again with small effect sizes. There are consistent associations between steeper temporal discounting and lower intelligence, with effect sizes exceeding those of personality or cognitive variables, although socio-demographic moderator variables may play a role. Neuroimaging evidence of brain structural and functional correlates is not yet consistent, neither with regard to areas nor directions of effects. Finally, following early candidate gene studies, recent Genome Wide Association Study (GWAS) approaches have revealed the molecular genetic architecture of temporal discounting to be more complex than initially thought. Overall, the study of individual differences in temporal discounting is a maturing field that has produced some replicable findings. Effect sizes are small-to-medium, necessitating future hypothesis-driven work that prioritizes large samples with adequate power calculations. More research is also needed regarding the neural origins of individual differences in temporal discounting as well as the mediating neural mechanisms of associations of temporal discounting with personality and cognitive variables. (shrink)

That philosophy exists, that it is possible, and that it has (and could still have) a future depends first and foremost on the existence of philosophers (necessarily considered in the plural). If the presence of philosophers is fundamental for the existence of the philosophical enterprise, then it can be easily deduced that, without philosophers, there would be no philosophy. If they come necessarily in the plural (as more than one), how should they, however, interact? Is philosophy a mere interaction among (...) philosophers, or is it a cooperation of philosophers? But maybe it is something different still. The concept of philosophy, in its original Greek understanding, reveals how this interaction can be understood in a provocative but very interesting way: as friendship. Philosophy as philo-sophy, as friendship of wisdom. Said differently, philosophy as a community (of friends) that gather around the question of wisdom and knowledge. This essay attempts to think philosophy according to its being φιλεῖν τὸ σοφόν. (shrink)

The observation that our world is signed by a lasting crisis is as much underwritten as it is questioned. This book offers a new and provocative thesis by taking recourse to the religious discourse of Limbo, and by investigating the temporal and spatial structures of crisis and modernity. Modernity reveals itself to be the state of perennial crisis, and we all live in an immanentized state of Limbo.

Aristoteles verweist bei verschiedenen Gelegenheiten für die weitere Diskussion von Fragen auf ›die Probleme‹. Gleichwohl können diese Verweise – mit vielleicht nur einer einzigen Ausnahme – nicht auf die im Corpus Aristotelicum unter dem Titel Problemata physica enthaltene Textsammlung referieren. Offenbar handelt es sich dabei um eine peripatetische Zusammenstellung, die häufig von theophrastischem oder sogar noch jüngerem Material abhängt.

We present the first comprehensive taxonomic revision and review the biology of the olingos, the endemic Neotropical procyonid genus Bassaricyon, based on most specimens available in museums, and with data derived from anatomy, morphometrics, mitochondrial and nuclear DNA, field observations, and geographic range modeling. Species of Bassaricyon are primarily forest-living, arboreal, nocturnal, frugivorous, and solitary, and have one young at a time. We demonstrate that four olingo species can be recognized, including a Central American species (Bassaricyon gabbii), lowland species with (...) eastern, cis-Andean (Bassaricyon alleni) and western, trans-Andean (Bassaricyon medius) distributions, and a species endemic to cloud forests in the Andes. The oldest evolutionary divergence in the genus is between this last species, endemic to the Andes of Colombia and Ecuador, and all other species, which occur in lower elevation habitats. Surprisingly, this Andean endemic species, which we call the Olinguito, has never been previously described; it represents a new species in the order Carnivora and is the smallest living member of the family Procyonidae. We report on the biology of this new species based on information from museum specimens, niche modeling, and fieldwork in western Ecuador, and describe four Olinguito subspecies based on morphological distinctions across different regions of the Northern Andes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.1 (2001) 139-141 [Access article in PDF] Helen S. Lang. The Order of Nature in Aristotle's Physics: Place and the Elements. Cambridge: Cambridge University Press, 1998. Pp. xii + 324. £40. This is an unsuccessful book. Some of the reasons for its failure are complex, others are more simple. I cannot address all, but shall simply discuss the fundamental claims about four large (...) topical units—about nature, place, void and elemental motion—indicating why they are untenable.Discussing the celebrated definition of nature in Physics II.1, Lang contends that in it the verb kineisthai should be taken in the passive voice, that nature should be understood as a principle or cause of being moved and of being at rest, and not just blandly as a principle of motion and rest. Since Aristotle asserts in Book VIII of the Physics that the elements contain a passive principle of motion (255b30f), Lang's contention would mean that the elements in this respect do not differ from other natural entities. This is highly unlikely, given the systematic contrast of self-moving composite natural entities and simple, unarticulated elemental natures at 255a5-18. Lang goes so far as to assert [End Page 139] that "kineisthai is always passive, not middle (or reflexive), in both Plato and Aristotle" (42). Fortunately, we need not accept this on her word: although kineisthai can be both passive and middle, in some instances (notably in aorist and future), passive and middle forms are different. Accordingly, Lang's claim must be rejected on the basis of the very first passage she helpfully quotes as an "additional example" in n.24 on p.42: Physics VII.1 242a37f employs the middle voice future, kinesétai, and not the passive form, kinethésetai. The passage, teeming with different forms of the verb kineisthai, describes an entity which contains the principle of motion in itself, which moves naturally. This indisputably shows that Lang's contention is wrong.Lang, contrary to the well-entrenched scholarly consensus, claims that place is not the first (=innermost) extremity or first unmoved boundary of the containing body, but the extremity of the first body, i.e., of the celestial sphere. (The transposition of the qualification "first" happens in several, non-conclusive installments, see e.g. 99f, or 106f.) This transposition, however, runs counter to several of Aristotle's stipulations about place. Lang's all-encompassing extremity can only be the common (koinos) place of everything there is, whereas Aristotle is keen on finding the proper or particular (idios) place, a location which contains nothing but the entity itself (209a32-b1). The entirety of the discussion in Physics IV.4-5 attests that it is this latter place which Aristotle defines here: the first place is neither smaller, nor bigger than the thing in place (211a1f, a23-29, a31-33, etc.). Aristotle repeatedly stresses that the extremities of the contained body and its container are "in the same" (211a33f, b11f). This remark surely would be out of place about the remote extremity of the first containing body. It is also repeatedly set out that the direction of explanation is bottom-up, and not top-down, as Lang's all-encompassing universal place would require: it is by being in a particular locus that we can be said to be in (the sphere of) air, and by this in the heaven (209a33-b1, 211a23-26).Lang's proposal is not just theoretically unappealing. The traditional should not be rejected recklessly, without an attentive discussion. After all, it "apparently beg[a]n immediately with Theophrastus," as Lang rather uncannily admits (105), and it was Theophrastus, and not Lang, who studied and worked for decades with Aristotle.A key assertion of the chapter on void also rests on a grave philological blunder. Lang argues that interpreters switched from Aristotle's expression "that through which" (to di' hou) to "medium," thereby surrendering the original net of notions, in which the natural activity of the element impeded the progression of the... (shrink)

We welcome Blair's argument that the relationship between fluid cognition and other aspects of intelligence should be an important focus of research, but are less convinced by his arguments that fluid intelligence is dissociable from general intelligence. This is due to confusions between (a) crystallized skills and g, and (b) universal and differential constructs. (Published Online April 5 2006).

The paper focuses on the thinking of Jonáš Záborský (1812–1876) and Štěpán Launer (1821–1851), which were marginalized in Slovak national-forming thinking. Emphasis is placed on the comparison between non-romantic nationalism and Štúr’s ethnic enthusiasm. Attention is paid to the value of their thinking, which can be analyzed in the context of reflections in the role of cultural identity in Štúr’s conception of culture and its place in relation to European cultural and civilizational affiliation. At the same time, the critique of (...) romantic thinking draws attention to the issue of the responsibility of nation-forming elites for the concept of civic development, which holistically approaches social change. Launer’s and, partly Záborský’s thinking draws attention to the dangers associated with the romantic search for ethnocultural specifics, which may result in the questioning the importance of civil liberties and Western cultural and civilizational affiliation. (shrink)

This chapter contains sections titled: The Principles of Physics The Science of Natural Beings Motion, Causal Interaction, and Causational Synonymy Aristotelian Kinematics Aristotle's Theory of the Continuum The Causes of Elemental Motions Unmoved Movers Bibliography.

The paper is about a chreia—a one-liner used as a grammatical exercise sentence—that presents Pythagoras as proscribing an expression from admissible linguistic usage. This injunction is funny, because it can be construed as Pythagoras railing against the use of a particular variant form of an adjective—and also as against the use of items denoted by that adjective. In the paper I add to this line of interpretation the further point that the chreia also claims that in this latter construal the (...) injunction was Pythagoras’s signature insight, making him the philosopher that he was. (shrink)

BackgroundRich in different kind of potent cells, embryos are used in modern regenerative medicine and research. Neurobiologists today are pushing the boundaries for what can be done with embryos existing in the transitory margins of medicine. Therefore, there is a growing need to develop conceptual frameworks for interpreting the transformative cultural, biological and technical processes involving these aborted, donated and marginal embryos. This article is a contribution to this development of frameworks.MethodsThis article examines different emotional, cognitive and discursive strategies used (...) by neurobiologists in a foetal cell transplantation trial in Parkinson’s disease research, using cells harvested from aborted embryos. Two interviews were analysed in the light of former observations in the processing laboratories, using the anthropologist Mary Douglas’s concept of pollution behaviour and the linguist, philosopher, psychoanalyst and feminist Julia Kristeva’s concept of the abjective to explain and make sense of the findings.ResultsThe findings indicate that the labour performed by the researchers in the trial work involves transforming the foetal material practically, as well as culturally, from trash to treasure. The transformation process contains different phases, and in the interview material we observed that the foetal material or cells were considered objects, subjects or rejected as abject by the researchers handling them, depending on what phase of process or practice they referred to or had experience of. As demonstrated in the analysis, it is the human origin of the cell that makes it abjective and activates pollution discourse, when the researchers talk of their practice.ConclusionsThe marginal and ambiguous status of the embryo that emerges in the accounts turns the scientists handling foetal cells into liminal characters in modern medicine. Focusing on how practical as well as emotional and cultural strategies and rationalizations of the researchers emerge in interview accounts, this study adds insights on the rationale of practically procuring, transforming and utilizing the foetal material to the already existing studies focused on the donations. We also discuss why the use and refinement of a tissue, around which there is practical consensus but cultural ambiguity, deserves further investigation. (shrink)

Gene-technology was developed in the eighties and stimulated an overmuch heated social debate. Let's think such problems as cloning, transgenic organisms, Human Genom Project, DNA diagnostics and therapy, the geneticalisation of society etc. While the gene manipulation develops rapidly the necessary social control is missing. Regarding the social co-ordination of gene technology, the decision-makers still excessively trust in the institution of market and in the experts' competence.

The study focuses on the ethical aspects of decision-making by national elites in the context of the thinking of Ján Kollár (1793–1852) and Ľudovít Štúr (1815–1856) on the issue of Slavism. Attention is paid to the issue of responsibility for preserving the greatness and unity of the nation in the context of the formation of national identity and individuality. The concepts of the mentioned authors had an impact on the cultural-civilizational orientation of Slovak elites with an emphasis on the role (...) of moral obligations in shaping the value orientation of the nation. In this context, the analysis focuses on the works Reciprocity between the various tribes and dialects of the Slavic nation and Slavdom and the world of the future, which, at the same time, represent alternative concepts of the cultural and political orientation of the Slavs. The study simultaneously analyses these concepts as alternative programs of cultural and political development of national identity, as well as concepts aimed at humanist and political goals. (shrink)

Entangled states provide the necessary tools for conceptual tests of quantum mechanics and other alternative theories. These tests include local hidden variables theories, pre- and postselective quantum mechanics, QND measurements, complementarity, and tests of quantum mechanics itself against, e.g., the so-called causal communication constraint. We show how to produce various nonlocal entangled states of multiple cavity fields that are useful for these tests, using cavity QED techniques. First, we discuss the generation of the Bell basis states in two entangled cavities, (...) when there is at most one photon in either of the cavities, and then a straightforward generalization to similar N-cavity states. We then show how to produce a nonlocal entangled state when there is precisely one photon hiding in three cavities. These states can be produced by sending appropriately prepared atoms through the cavities. As applications we briefly review two proposals: one to test quantum mechanics against the causal communication constraint using a two-cavity entangled state and the other to test pre- and postselective quantum mechanics using a three-cavity entangled state. The outcome of the latter experiment can be discussed from the viewpoint of the consistent histories interpretation of quantum mechanics and therefore provides an opportunity to subject quantum cosmological ideas to laboratory tests. Finally, we point out the relation between these schemes and the schemes suggested for quantum computing, teleportation, and quantum copying. (shrink)

As narrative conceptions of selfhood have gained more acceptance within various disciplines including philosophy, psychology, and the cognitive sciences, so too have these conceptions been critically appraised. Chief among those who are suspicious of the overall viability of ‘narrative identity’ is the philosopher, Galen Strawson. In this paper, I develop five arguments underlying Strawson’s critique of narrative identity, and respond to each argument from the perspective of the hermeneutic phenomenology of Paul Ricœur. Though intuitive, I demonstrate that none of Strawson’s (...) arguments are cogent. The confrontation between these two figures highlights a deep conceptual disagreement about our epistemic access to the self, which has thus far gone unrecognized in the Anglo-American discussion, so that it raises a new problem for the metaphysics of personal identity. (shrink)